A Comprehensive Coexpression Network Analysis in Vibrio cholerae.

ABSTRACT: Research into the evolution and pathogenesis of Vibrio cholerae has benefited greatly from the generation of high-throughput sequencing data to drive molecular analyses. The steady accumulation of these data sets now provides a unique opportunity for in silico hypothesis generation via coexpression analysis. Here, we leverage all published V. cholerae RNA sequencing data, in combination with select data from other platforms, to generate a gene coexpression network that validates known gene interactions and identifies novel genetic partners across the entire V. cholerae genome. This network provides direct insights into genes influencing pathogenicity, metabolism, and transcriptional regulation, further clarifies results from previous sequencing experiments in

SUBMITTER: DuPai CD 

PROVIDER: S-EPMC7343309 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature