Bioinformatics analysis of high-throughput data to validate potential novel biomarkers and small molecule drugs for glioblastoma multiforme.

ABSTRACT:

Objective

There have been no recent improvements in the glioblastoma multiforme (GBM) outcome, with median survival remaining 15 months. Consequently, the need to identify novel biomarkers for GBM diagnosis and prognosis, and to develop targeted therapies is high. This study aimed to establish biomarkers for GBM pathogenesis and prognosis.

Methods

In total, 220 overlapping differentially expressed genes (DEGs) were obtained by integrating four microarray datasets from the Gene Expression Omnibus database (GSE4290, GSE12657, GSE15824, and GSE68848). Then a 140-node protein-protein interaction network with 343 interactions was constructed.

Results

The immune response and cell adhesion molecules were the most significantly enriched functions and pathways, respectively, a

SUBMITTER: Qi F 

PROVIDER: S-EPMC7343367 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature