Ovarian aging increases small extracellular vesicle CD81⁺ release in human follicular fluid and influences miRNA profiles.

ABSTRACT: Ovarian aging affects female reproductive potential and is characterized by alterations in proteins, mRNAs and non-coding RNAs inside the ovarian follicle. Ovarian somatic cells and the oocyte communicate with each other secreting different molecules into the follicular fluid, by extracellular vesicles. The cargo of follicular fluid vesicles may influence female reproductive ability; accordingly, analysis of extracellular vesicle content could provide information about the quality of the female germ cell.In order to identify the most significant deregulated microRNAs in reproductive aging, we quantified the small extracellular vesicles in human follicular fluid from older and younger women and analyzed the expression of microRNAs enclosed inside the vesicles. We found twice as many small e

SUBMITTER: Battaglia R 

PROVIDER: S-EPMC7343446 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature