A new risk model comprising genes highly correlated with CD133 identifies different tumor-immune microenvironment subtypes impacting prognosis in hepatocellular carcinoma.

ABSTRACT: The existence of cancer stem cells (CSCs), marked by CD133, is the primary cause of death in hepatocellular carcinoma (HCC). Here, we generated a new risk model comprising the signatures of four genes highly correlated with CD133 (CD133_(hi)) that help improve survival in HCC. Three datasets were used to identify the differential CD133_(hi) genes by comparing sorted CD133⁺ liver CSCs and CD133^- differentiated counterparts. Univariate analysis was used to screen significantly differential CD133_(hi) genes associated with overall survival in the training dataset, which were used for risk model construction. High-risk patients were strongly associated with poor survival by Kaplan-Meier survival analysis in both the training and validation da

SUBMITTER: Yu H 

PROVIDER: S-EPMC7343494 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature