Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation.

ABSTRACT:

Background

In animal studies early life antibiotic exposure causes metabolic abnormalities including obesity through microbiota disruption, but evidence from human studies is scarce. We examined involvement of gut microbiota in the associations between infant antibiotic exposure and childhood adiposity.

Methods

Infant antibiotic exposure in the first year of life was ascertained using parental reports during interviewer-administered questionnaires. Primary outcomes were childhood obesity [body mass index (BMI) z-score > 95th percentile] and adiposity [abdominal circumference (AC) and skinfold (triceps + subscapular (SST)) measurements] determined from ages 15-60 months. At age 24 months, when the gut microbiota are more stable, stool samples (n = 392) were collected for the

SUBMITTER: Chen LW 

PROVIDER: S-EPMC7343523 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature