Generic dynamic causal modelling: An illustrative application to Parkinson's disease.

ABSTRACT: We present a technical development in the dynamic causal modelling of electrophysiological responses that combines qualitatively different neural mass models within a single network. This affords the option to couple various cortical and subcortical nodes that differ in their form and dynamics. Moreover, it enables users to implement new neural mass models in a straightforward and standardized way. This generic framework hence supports flexibility and facilitates the exploration of increasingly plausible models. We illustrate this by coupling a basal ganglia-thalamus model to a (previously validated) cortical model developed specifically for motor cortex. The ensuing DCM is used to infer pathways that contribute to the suppression of beta oscillations induced by dopaminergic medication in

SUBMITTER: van Wijk BCM 

PROVIDER: S-EPMC7343527 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature