Upregulation of Multiple CD8⁺ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection.

ABSTRACT: A large proportion of the world's population harbors latent HSV type 1 (HSV-1). Cross-talk between antiviral CD8⁺ T cells and HSV-1 appear to control latency/reactivation cycles. We found that compared with healthy asymptomatic individuals, in symptomatic (SYMP) patients, the CD8⁺ T cells with the same HLA-A*0201-restricted HSV-1 epitope specificities expressed multiple genes and proteins associated to major T cell exhaustion pathways and were dysfunctional. Blockade of immune checkpoints with anti-LAG-3 and anti-PD-1 antagonist mAbs synergistically restored the frequency and function of antiviral CD8⁺ T cells, both 1) ex vivo, in SYMP individuals and SYMP HLA-A*0201 transgenic mice; and 2) in vivo in HSV-1-infected SYMP HLA-A*0201 transgenic mice. This was

SUBMITTER: Coulon PG 

PROVIDER: S-EPMC7343593 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature