Exploiting Pre-Existing CD4⁺ T Cell Help from Bacille Calmette-Guerin Vaccination to Improve Antiviral Antibody Responses.

ABSTRACT: The continuing emergence of viral pathogens and their rapid spread into heavily populated areas around the world underscore the urgency for development of highly effective vaccines to generate protective antiviral Ab responses. Many established and newly emerging viral pathogens, including HIV and Ebola viruses, are most prevalent in regions of the world in which Mycobacterium tuberculosis infection remains endemic and vaccination at birth with M. bovis bacille Calmette-Guérin (BCG) is widely used. We have investigated the potential for using CD4⁺ T cells arising in response to BCG as a source of help for driving Ab responses against viral vaccines. To test this approach, we designed vaccines comprised of protein immunogens fused to an immunodominant CD4⁺

SUBMITTER: Ng TW 

PROVIDER: S-EPMC7343599 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature