Ontology highlight
ABSTRACT:
SUBMITTER: Reiter JG
PROVIDER: S-EPMC7343611 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nature genetics 20200525 7
Genetic diversity among metastases is poorly understood but contains important information about disease evolution at secondary sites. Here we investigate inter- and intra-lesion heterogeneity for two types of metastases that associate with different clinical outcomes: lymph node and distant organ metastases in human colorectal cancer. We develop a rigorous mathematical framework for quantifying metastatic phylogenetic diversity. Distant metastases are typically monophyletic and genetically simi ...[more]