Ontology highlight
ABSTRACT:
SUBMITTER: Prendergast L
PROVIDER: S-EPMC7343669 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Oncogene 20200612 28
The histone chaperone FACT is upregulated during mammary tumorigenesis and necessary for the viability and growth of breast tumor cells. We established that only proliferating tumor cells are sensitive to FACT knockdown, suggesting that FACT functions during DNA replication in tumor cells but not in normal cells. We hypothesized that the basal level of replication stress defines the FACT dependence of cells. Using genetic and chemical tools, we demonstrated that FACT is needed to overcome replic ...[more]