Kinfitr - an open-source tool for reproducible PET modelling: validation and evaluation of test-retest reliability.

ABSTRACT:

Background

In positron emission tomography (PET) imaging, binding is typically estimated by fitting pharmacokinetic models to the series of measurements of radioactivity in the target tissue following intravenous injection of a radioligand. However, there are multiple different models to choose from and numerous analytical decisions that must be made when modelling PET data. Therefore, it is important that analysis tools be adapted to the specific circumstances, and that analyses be documented in a transparent manner. Kinfitr, written in the open-source programming language R, is a tool developed for flexible and reproducible kinetic modelling of PET data, i.e. performing all steps using code which can be publicly shared in analysis notebooks. In this study, we compared outcomes ob

SUBMITTER: Tjerkaski J 

PROVIDER: S-EPMC7343683 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature