Impact of β-glycerophosphate on the bioenergetic profile of vascular smooth muscle cells.

ABSTRACT: In chronic kidney disease, hyperphosphatemia is a key pathological factor promoting medial vascular calcification, a common complication associated with cardiovascular events and mortality. This active pathophysiological process involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs) via complex intracellular mechanisms that are still incompletely understood. Little is known about the effects of phosphate on the bioenergetic profile of VSMCs during the onset of this process. Therefore, the present study explored the effects of the phosphate donor β-glycerophosphate on cellular bioenergetics of VSMCs. Mitochondrial and glycolytic functions were determined utilizing extracellular flux analysis in primary human aortic VSMCs following exposure to β-glycerophos

SUBMITTER: Alesutan I 

PROVIDER: S-EPMC7343738 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature