Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis.

ABSTRACT: Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.

SUBMITTER: Garelli CJ 

PROVIDER: S-EPMC7343764 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature