The Acute and Early Effects of Whole-Brain Irradiation on Glial Activation, Brain Metabolism, and Behavior: a Positron Emission Tomography Study.

ABSTRACT:

Purpose

Radiotherapy is a frequently applied treatment modality for brain tumors. Concomitant irradiation of normal brain tissue can induce various physiological responses. The aim of this study was to investigate whether acute and early-delayed effects of brain irradiation on glial activation and brain metabolism can be detected with positron emission tomography (PET) and whether these effects are correlated with behavioral changes.

Procedures

Rats underwent 0-, 10-, or 25-Gy whole-brain irradiation. At 3 and 31 days post irradiation, 1-(2-chlorophenyl)-N-[¹¹C]methyl-(1-methylpropyl)-3-isoquinoline carboxamide ([¹¹C]PK11195) and 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) PET scans were acquired to detect changes in glial activatio

SUBMITTER: Parente A 

PROVIDER: S-EPMC7343765 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature