In vivo human brain expression of histone deacetylases in bipolar disorder.

ABSTRACT: The etiology of bipolar disorder (BD) is unknown and the neurobiological underpinnings are not fully understood. Both genetic and environmental factors contribute to the risk of BD, which may be linked through epigenetic mechanisms, including those regulated by histone deacetylase (HDAC) enzymes. This study measures in vivo HDAC expression in individuals with BD for the first time using the HDAC-specific radiotracer [¹¹C]Martinostat. Eleven participants with BD and 11 age- and sex-matched control participants (CON) completed a simultaneous magnetic resonance - positron emission tomography (MR-PET) scan with [¹¹C]Martinostat. Lower [¹¹C]Martinostat uptake was found in the right amygdala of BD compared to CON. We assessed uptake in the dorsolateral prefrontal

SUBMITTER: Tseng CJ 

PROVIDER: S-EPMC7343804 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature