New Insights Into DNA Repair Revealed by NucS Endonucleases From Hyperthermophilic Archaea.

ABSTRACT: Hyperthermophilic Archaea (HA) thrive in high temperature environments and their genome is facing severe stability challenge due to the increased DNA damage levels caused by high temperature. Surprisingly, HA display spontaneous mutation frequencies similar to mesophilic microorganisms, thereby indicating that the former must possess more efficient DNA repair systems than the latter to counteract the potentially enhanced mutation rates under the harsher environment. Although a few repair proteins or enzymes from HA have been biochemically and structurally characterized, the molecular mechanisms of DNA repair of HA remain largely unknown. Genomic analyses of HA revealed that they lack MutS/MutL homologues of the mismatch repair (MMR) pathway and the recognition proteins of the nucleotide ex

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7343888 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature