CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204.

ABSTRACT:

Background

Numerous studies have found that circular RNAs (circRNA) can serve as competing endogenous RNA (ceRNA) in cancer progression while the expression profiles and functions of competitive endogenous circRNAs (ce-circRNAs) in breast cancer (BC) have not been determined.

Methods

Six pairs of tissue samples were selected to perform ceRNA microarray, and The Cancer Genome Atlas (TCGA) data was also included to explore the ce-circRNA profiling of BC. The expression of one of the top upregulated circRNAs, circMMP11, was confirmed by qRT-PCR in both breast cancer cell lines and tissues. We also analyzed the clinical impact of circMMP11 on BC. To explore the functions of circMMP11 in BC, experiments referring to cell proliferation and migration were performed. The regulatory

SUBMITTER: Li Z 

PROVIDER: S-EPMC7344057 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature