Genome-Wide Identification and Analysis of Enhancer-Regulated microRNAs Across 31 Human Cancers.

ABSTRACT: Enhancers are cis-regulatory DNA elements that positively regulate the transcription of target genes in a tissue-specific manner, and dysregulation of target genes could lead to various diseases, such as cancer. Recent studies have shown that enhancers can regulate microRNAs (miRNAs) and participate in their biological synthesis. However, the network of enhancer-regulated miRNAs across multiple cancers is still unclear. Here, a total of 2,418 proximal enhancer-miRNA interactions and 1,280 distal enhancer-miRNA interactions were identified through the integration of genomic distance, co-expression, and 3D genome data in 31 cancers. The results showed that both proximal and distal interactions exhibited a significant cancer type-specific feature trend at the tissue level rather than a

SUBMITTER: Tang F 

PROVIDER: S-EPMC7344161 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature