The Contribution of Race to Breast Tumor Microenvironment Composition and Disease Progression.

ABSTRACT: Breast cancer is the second most commonly diagnosed cancer in American women following skin cancer. Despite overall decrease in breast cancer mortality due to advances in treatment and earlier screening, black patients continue to have 40% higher risk of breast cancer related death compared to white patients. This disparity in outcome persists even when controlled for access to care and stage at presentation and has been attributed to differences in tumor subtypes or gene expression profiles. There is emerging evidence that the tumor microenvironment (TME) may contribute to the racial disparities in outcome as well. Here, we provide a comprehensive review of current literature available regarding race-dependent differences in the TME. Notably, black patients tend to have a higher density o

SUBMITTER: Kim G 

PROVIDER: S-EPMC7344193 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature