Therapeutic enhancement of blood-brain and blood-tumor barriers permeability by laser interstitial thermal therapy.

ABSTRACT:

Background

The blood-brain and blood-tumor barriers (BBB and BTB), which restrict the entry of most drugs into the brain and tumor, respectively, are a significant challenge in the treatment of glioblastoma. Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique increasingly used clinically for tumor cell ablation. Recent evidence suggests that LITT might locally disrupt BBB integrity, creating a potential therapeutic window of opportunity to deliver otherwise brain-impermeant agents.

Methods

We established a LITT mouse model to test if laser therapy can increase BBB/BTB permeability in vivo. Mice underwent orthotopic glioblastoma tumor implantation followed by LITT in combination with BBB tracers or the anticancer drug doxorubicin. BBB/BTB perm

SUBMITTER: Salehi A 

PROVIDER: S-EPMC7344247 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature