Efficacy and Safety of Recombinant Human Thrombopoietin on Sepsis Patients With Thrombocytopenia: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

The efficacy and safety of the administration of recombinant human thrombopoietin (rhTPO) in sepsis patients with thrombocytopenia were still inconclusive.

Objectives

To investigate whether rhTPO is a benefit for sepsis patients with thrombocytopenia.

Methods

PubMed, Cochrane library, Embase, China National Knowledge Infrastructure, and Wanfang Database were electronically searched to the randomized controlled trials (RCTs) from inception to March 4, 2020. The primary outcome was the level of platelet (PLT) on the 7^th day of treatment, and secondary outcomes were 28-d mortality, the level of coagulation indicators, hepatic and renal function indicators, blood transfusion, and length of intensive care unit (ICU) stay.

Results

Ten RCTs invol

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7344265 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature