Antibiotic-Induced Changes in Microbiome-Related Metabolites and Bile Acids in Rat Plasma.

ABSTRACT: Various environmental factors can alter the gut microbiome's composition and functionality, and modulate host health. In this study, the effects of oral and parenteral administration of two poorly bioavailable antibiotics (i.e., vancomycin and streptomycin) on male Wistar Crl/Wi(Han) rats for 28 days were compared to distinguish between microbiome-derived or -associated and systemic changes in the plasma metabolome. The resulting changes in the plasma metabolome were compared to the effects of a third reference compound, roxithromycin, which is readily bioavailable. A community analysis revealed that the oral administration of vancomycin and roxithromycin in particular leads to an altered microbial population. Antibiotic-induced changes depending on the administration routes were observed

SUBMITTER: de Bruijn V 

PROVIDER: S-EPMC7344402 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature