Label-Free Electrochemical Microfluidic Chip for the Antimicrobial Susceptibility Testing.

ABSTRACT: The emergence and spread of antibiotic-resistant bacteria is a global threat to human health. An accurate antibiotic susceptibility test (AST) before initiating the treatment is paramount in the treatment and bacterial resistance control. However, the current AST methods either are complex, use chemical and biological labels, lack multiplexing, are expensive, or are too slow to be used for routine screening. The primary objective of the current study is to develop an automated electrochemical microfluidic chip (EMC) for simple and rapid AST. The microfluidic channels and gold microelectrodes were designed for the automation of antibiotic mixing and distribution in multiple test chambers and for electrical signal measurements. The designed chip was tested for AST with E. coli samples, and t

SUBMITTER: Jeon H 

PROVIDER: S-EPMC7344617 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature