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Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.

ABSTRACT: Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4, which, in turn, was obtained from the marine algae Sargassum thunbergii. The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well as high resolution fast atom bombardment mass (HRFABMS) spectral analysis. The absolute stereochemistry was determined via chemical derivatization and comparison with a known compound, (6R,11R,12R,14R)-colletodiol. Additionally, halosmysin A was shown to be very potent against murine P388 leukemia, human HL-60 leukemia, and murine L1210 leukemia cell lines, with IC50 values ranging from 2.2 ± 3.1 to 11.7 ± 2.8 μM.

SUBMITTER: Yamada T 

PROVIDER: S-EPMC7344848 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus <i>Halosphaeriaceae</i> sp.

Yamada Takeshi T   Kogure Haruka H   Kataoka Minami M   Kikuchi Takashi T   Hirano Tomoya T  

Marine drugs 20200618 6

Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus <i>Halosphaeriaceae</i> sp. OUPS-135D-4, which, in turn, was obtained from the marine algae <i>Sargassum thunbergii.</i> The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well as high resolution fast atom bombardment mass (HRFABMS) spectral analysis. The absolute stereochemistry was determined via chemical derivatization and comparison with a known compound, (  ...[more]