Negative Correlation between Lipid Content and Antibiotic Activity in Streptomyces: General Rule and Exceptions.

ABSTRACT: Streptomycetes are well known antibiotic producers and are among the rare prokaryotes able to store carbon as lipids. Previous comparative studies of the weak antibiotic producer Streptomyces lividans with its ppk mutant and with Streptomyces coelicolor, which both produce antibiotics, suggested the existence of a negative correlation between total lipid content and the ability to produce antibiotics. To determine whether such a negative correlation can be generalized to other Streptomyces species, fifty-four strains were picked randomly and grown on modified R2YE medium, limited in phosphate, with glucose or glycerol as the main carbon source. The total lipid content and antibiotic activity against Micrococcus luteus were assessed for each strain. This s

SUBMITTER: David M 

PROVIDER: S-EPMC7344866 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature