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"Noninfective Endocarditis": A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male.


ABSTRACT: We report a case of a young male who presented with acute limb ischemia after sport. With no prior history of disease, a non-infective endocarditis of the native aortic valve was diagnosed. After surgical valve replacement, the patient suffered from acute myocardial ischemia under phenprocoumon therapy. Anti-coagulant monitoring was subsequently changed to Factor II analysis after a rare Factor VII deficiency and prothrombin mutation (G20210A) was diagnosed.

SUBMITTER: Reid G 

PROVIDER: S-EPMC7345217 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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"Noninfective Endocarditis": A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male.

Reid Gregory G   Koechlin Luca L   Reuthebuch Oliver O   Rüter Florian F   Hopfer Helmut H   Eckstein Friedrich F   Santer David D  

Diagnostics (Basel, Switzerland) 20200608 6


We report a case of a young male who presented with acute limb ischemia after sport. With no prior history of disease, a non-infective endocarditis of the native aortic valve was diagnosed. After surgical valve replacement, the patient suffered from acute myocardial ischemia under phenprocoumon therapy. Anti-coagulant monitoring was subsequently changed to Factor II analysis after a rare Factor VII deficiency and prothrombin mutation (G20210A) was diagnosed. ...[more]

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