Identification of Novel Native Autoantigens in Rheumatoid Arthritis.

ABSTRACT: The majority of patients diagnosed with rheumatoid arthritis (RA) have developed autoantibodies against neoepitopes in proteins that have undergone post-translational modification, e.g., citrullination or carbamylation. There is growing evidence of their molecular relevance and their potential utility to improve diagnosis, patient stratification, and prognosis for precision medicine. Autoantibodies reacting to native proteins may also have a role in RA pathogenesis, however, their reactivity patterns remain much less studied. We hypothesized that a high-density protein array technology could shed light onto the normal and disease-related autoantibodies produced in healthy and RA patient subgroups. In an exploratory study, we investigated the global reactivity of autoantibodies in plasma po

SUBMITTER: Poulsen TBG 

PROVIDER: S-EPMC7345460 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature