STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects.

ABSTRACT: Molecular signaling pathways play a significant role in the regulation of biological mechanisms, and their abnormal expression can provide the conditions for cancer development. The signal transducer and activator of transcription 3 (STAT3) is a key member of the STAT proteins and its oncogene role in cancer has been shown. STAT3 is able to promote the proliferation and invasion of cancer cells and induces chemoresistance. Different downstream targets of STAT3 have been identified in cancer and it has also been shown that microRNA (miR), long non-coding RNA (lncRNA) and other molecular pathways are able to function as upstream mediators of STAT3 in cancer. In the present review, we focus on the role and regulation of STAT3 in gastric cancer (GC). miRs and lncRNAs are considered as potentia

SUBMITTER: Ashrafizadeh M 

PROVIDER: S-EPMC7345582 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature