Development of a Simple Kinetic Mathematical Model of Aggregation of Particles or Clustering of Receptors.

ABSTRACT: The process of clustering of plasma membrane receptors in response to their agonist is the first step in signal transduction. The rate of the clustering process and the size of the clusters determine further cell responses. Here we aim to demonstrate that a simple 2-differential equation mathematical model is capable of quantitative description of the kinetics of 2D or 3D cluster formation in various processes. Three mathematical models based on mass action kinetics were considered and compared with each other by their ability to describe experimental data on GPVI or CR3 receptor clustering (2D) and albumin or platelet aggregation (3D) in response to activation. The models were able to successfully describe experimental data without losing accuracy after switching between complex and simpl

SUBMITTER: Garzon Dasgupta AK 

PROVIDER: S-EPMC7345685 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature