Antifungal Resistance Regarding Malassezia pachydermatis: Where Are We Now?

ABSTRACT: Malassezia pachydermatis is a yeast inhabiting the skin and ear canals in healthy dogs. In the presence of various predisposing conditions it can cause otitis and dermatitis, which are treated with multiple antifungal agents, mainly azole derivatives. This manuscript aims to review the available evidence regarding the occurrence of resistance phenomena in this organism. Various findings support the capacity of M. pachydermatis for developing resistance. These include some reports of treatment failure in dogs, the reduced antifungal activity found against yeast isolates sampled from dogs with exposure to antifungal drugs and strains exposed to antifungal agents in vitro, and the description of resistance mechanisms. At the same time, the data reviewed may suggest that the development of res

SUBMITTER: Peano A 

PROVIDER: S-EPMC7345795 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature