Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia.

ABSTRACT: The auditory mismatch negativity (MMN) is a translatable electroencephalographic biomarker automatically evoked in response to unattended sounds that is robustly associated with cognitive and psychosocial disability in patients with schizophrenia. Although recent animal studies have tried to clarify the neural substrates of the MMN, the nature of schizophrenia-related deficits is unknown. In this study, we applied a novel paradigm developed from translational animal model studies to carefully deconstruct the constituent neurophysiological processes underlying MMN generation. Patients with schizophrenia (N = 25) and healthy comparison subjects (HCS; N = 27) underwent MMN testing using both a conventional auditory oddball paradigm and a "many-standards paradigm" that was specifically develop

SUBMITTER: Koshiyama D 

PROVIDER: S-EPMC7345817 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature