Network Organization of Antibody Interactions in Sequence and Structure Space: the RADARS Model.

ABSTRACT: Adaptive immunity in vertebrates is a complex self-organizing network of molecular interactions. While deep sequencing of the immune-receptor repertoire may reveal clonal relationships, functional interpretation of such data is hampered by the inherent limitations of converting sequence to structure to function. In this paper, a novel model of antibody interaction space and network, termed radial adjustment of system resolution, RAdial ADjustment of System Resolution (RADARS), is proposed. The model is based on the radial growth of interaction affinity of antibodies towards an infinity of directions in structure space, each direction corresponding to particular shapes of antigen epitopes. Levels of interaction affinity appear as free energy shells of the system, where hierarchical B-cell d

SUBMITTER: Prechl J 

PROVIDER: S-EPMC7345901 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature