Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage.

ABSTRACT: The progress in the discovery and validation of metabolite biomarkers for the detection of colorectal cancer (CRC) has been hampered by the lack of reproducibility between study cohorts. The majority of discovery-phase biomarker studies have used patient blood samples to identify disease-related metabolites, but this pre-validation phase is confounded by non-specific disease influences on the metabolome. We therefore propose that metabolite biomarker discovery would have greater success and higher reproducibility for CRC if the discovery phase was conducted in tumor tissues, to find metabolites that have higher specificity to the metabolic consequences of the disease, that are then validated in blood samples. This would thereby eliminate any non-tumor and/or body response effects to the di

SUBMITTER: Cai Y 

PROVIDER: S-EPMC7345993 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature