Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030.

ABSTRACT: Acinetobacter baumannii is an important nosocomial bacterial pathogen. Multidrug-resistant isolates of A. baumannii are reported worldwide. Some A. baumannii isolates display resistance to nearly all antibiotics, making treatment of infections very challenging. As the need for new and effective antibiotics against A. baumannii becomes increasingly urgent, there is a need to understand the mechanisms of antibiotic resistance and virulence in this organism. In this work, comparative genomics was used to understand the mechanisms of antibiotic resistance and virulence in AB030, an extremely drug-resistant and hypervirulent strain of A. baumannii that is a representative of a recently emerged lineage of A. baumannii International Clone V. In order to characterize AB030, we carried out a genomi

SUBMITTER: Singh M 

PROVIDER: S-EPMC7345994 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature