Photoprotective Effects of Selected Amino Acids on Naproxen Photodegradation in Aqueous Media.

ABSTRACT: It is important to develop a photostabilization strategy to ensure the quality of photosensitive compounds, including pharmaceuticals. This study focused on the protective effects of 20 amino acids on the photodegradation of naproxen (NX), a photosensitive pharmaceutical, to clarify the important nature of a good photostabilizer. Our previous report indicated the photodegradability of NX and the protective effects of some antioxidants on its photodegradation, therefore, this compound was used as a model compound. The degradation of NX in aqueous media during ultraviolet light (UV) irradiation and the protective effects of selected amino acids were monitored through high-performance liquid chromatography (HPLC), equipped with a reverse-phase column. Addition of cysteine, tryptophan, and tyr

SUBMITTER: Kawabata K 

PROVIDER: S-EPMC7345999 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature