T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice.

ABSTRACT: Aging is a natural human process. It is uniquely individual, taking into account experiences, lifestyle habits and environmental factors. However, many disorders and syndromes, such as osteoporosis, neurodegenerative disorders, cognitive decline etc., often come with aging. The present study was designed to investigate the possible anti-aging effect of N⁶-(4-hydroxybenzyl)adenine riboside (T1-11), an adenosine analog isolated from Gastrodia elata, in a mouse model of aging created by D-galactose (D-gal) and the underlying mechanism, as well as explore the role of adenosine signaling in aging. T1-11 activated A_2AR and suppressed D-gal- and BeSO₄-induced cellular senescence in vitro. In vivo results in mice revealed that T1-11 abat

SUBMITTER: Hsu WH 

PROVIDER: S-EPMC7346012 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature