In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM.

ABSTRACT: Natural products continue to be major sources of bioactive compounds and drug candidates not only because of their unique chemical structures but also because of their overall favorable metabolism and pharmacokinetic properties. The number of publicly accessible natural product databases has increased significantly in the past few years. However, the systematic ADME/Tox profile has been reported on a limited basis. For instance, BIOFACQUIM was recently published as a public database of natural products from Mexico, a country with a rich source of biomolecules. However, its ADME/Tox profile has not been reported. Herein, we discuss the results of an in-depth in silico ADME/Tox profile of natural products in BIOFACQUIM and other large public collections of natural products. It was con

SUBMITTER: Duran-Iturbide NA 

PROVIDER: S-EPMC7346235 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature