Trajectories of Non-HDL Cholesterol Across Midlife: Implications for Cardiovascular Prevention.

ABSTRACT: BACKGROUND:Extended elevations of non-high-density lipoprotein cholesterol (non-HDL-C) across a lifespan are associated with increased risk of cardiovascular disease (CVD). However, optimal testing intervals to identify individuals with high lipid-related CVD risk are unknown. OBJECTIVES:This study determined the extent to which lipid levels in young adulthood predict future lipid trajectories and associated long-term CVD risk. METHODS:A sample of 2,516 Framingham Offspring study participants 25 to 40 years of age free of CVD and diabetes had their non-HDL-C progression modeled over 8 study examinations (mean follow-up 32.6 years) using group-based methods. CVD risk based on 25 to 30 years of follow-up was evaluated using Kaplan-Meier analyses for those with mean non-HDL-C ≥160 mg/dl ("hig

SUBMITTER: Pencina KM 

PROVIDER: S-EPMC7346311 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature