Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion.

ABSTRACT:

Background

Stimulation of trigeminovascular pathway is widely used to establish the headache animal model. Headache is a common neurological disorder, in which symptomatic attacks are mediated by calcitonin-gene-related peptide (CGRP). CGRP is synthesized and released from the trigeminal ganglion to transmit pain signals under stimulation. On the other hand, Neuropeptide FF (NPFF) is a candidate transmitter/modulator for migraine, and stimulation of its receptor, NPFFR2, increases the expression and release of CGRP in mice sensory neurons. Here, we investigate the impact of NPFFR2 on trigeminal CGRP level in a capsaicin-induced headache mouse model.

Methods

Mice were intracisternally injected with capsaicin into the cisterna magna to activate the trigeminovascular pathway an

SUBMITTER: Lin YT 

PROVIDER: S-EPMC7346335 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature