Pregnancy-induced changes in serum concentrations of perfluoroalkyl substances and the influence of kidney function.

ABSTRACT: BACKGROUND:Epidemiological associations between maternal concentrations of perfluoroalkyl substances (PFAS) and birth weight are inconsistent. There is concern that studies based on samples collected in late pregnancy may be confounded by kidney function but studies of the relation between pregnancy-induced changes in PFAS and kidney function are lacking. Our aims were to investigate changes in serum concentrations of perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) from early to late pregnancy and to explore relations to changes in glomerular filtration rate (GFR) and glomerular pore size. METHODS:We conducted the study in a cohort of 73 pregnancies of normal-weight Swedish women without gestational diabet

SUBMITTER: Nielsen C 

PROVIDER: S-EPMC7346349 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature