A common variant of the NOTCH4 gene modulates functional connectivity of the occipital cortex and its relationship with schizotypal traits.

ABSTRACT:

Background

Schizotypal traits are considered as inheritable traits and the endophenotype for schizophrenia. A common variant in the NOTCH4 gene, rs204993, has been linked with schizophrenia, but the neural underpinnings are largely unknown.

Methods

In present study, we compared the differences of brain functions between different genotypes of rs204993 and its relationship with schizotypal traits among 402 Chinese Han healthy volunteers. The brain function was evaluated with functional connectivity strength (FCS) using the resting-state functional magnetic resonance image(rs-fMRI). The schizotypal traits were measured by the schizotypal personality questionnaire (SPQ).

Results

Our results showed that carriers with the AA genotype showed reduced FCS in the left occipita

SUBMITTER: Xie X 

PROVIDER: S-EPMC7346398 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature