Exercise promotes satellite cell contribution to myofibers in a load-dependent manner.

ABSTRACT:

Background

Satellite cells (SCs) are required for muscle repair following injury and are involved in muscle remodeling upon muscular contractions. Exercise stimulates SC accumulation and myonuclear accretion. To what extent exercise training at different mechanical loads drive SC contribution to myonuclei however is unknown.

Results

By performing SC fate tracing experiments, we show that 8 weeks of voluntary wheel running increased SC contribution to myofibers in mouse plantar flexor muscles in a load-dependent, but fiber type-independent manner. Increased SC fusion however was not exclusively linked to muscle hypertrophy as wheel running without external load substantially increased SC fusion in the absence of fiber hypertrophy. Due to nuclear propagation, nuclear fluoresce

SUBMITTER: Masschelein E 

PROVIDER: S-EPMC7346400 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature