Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies.

ABSTRACT:

Objectives

To investigate using quantitative EEG the (1) differences between patients with mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with Alzheimer's disease (MCI-AD) and (2) its utility as a potential biomarker for early differential diagnosis.

Methods

We analyzed eyes-closed, resting-state, high-density EEG data from highly phenotyped participants (39 MCI-LB, 36 MCI-AD, and 31 healthy controls). EEG measures included spectral power in different frequency bands (delta, theta, pre-alpha, alpha, and beta), theta/alpha ratio, dominant frequency, and dominant frequency variability. Receiver operating characteristic (ROC) analyses were performed to assess diagnostic accuracy.

Results

There was a shift in power from beta and alpha frequency bands towards

SUBMITTER: Schumacher J 

PROVIDER: S-EPMC7346501 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature