Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair.

ABSTRACT:

Background

Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study is to investigate whether exosomes derived from human umbilical cord MSCs (UMSCs) could enhance the activities of bone marrow MSCs from old person (OMSCs), and improve their capacity for cardiac repair.

Methods

Exosomes extracted from conditioned medium of UMSCs were used to treat OMSCs to generate OMSCs^Exo. The key molecule in the exosomes that have potential to rejuvenate aged MSCs were screened, and the role of OMSC was tested in the mouse model of mycardial infarction (MI).

Results

We found the activity of senescence-associated β-galactos

SUBMITTER: Zhang N 

PROVIDER: S-EPMC7346506 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature