Increased density and age-related sharing of synapses at the cone to OFF bipolar cell synapse in the mouse retina.

ABSTRACT: Neural circuits in the adult nervous system are characterized by stable, cell type-specific patterns of synaptic connectivity. In many parts of the nervous system these patterns are established during development through initial over-innervation by multiple pre- or postsynaptic targets, followed by a process of refinement that takes place during development and is in many instances activity dependent. Here we report on an identified synapse in the mouse retina, the cone photoreceptor➔type 4 bipolar cell (BC4) synapse, and show that its development is distinctly different from the common motif of over-innervation followed by refinement. Indeed, the majority of cones are contacted by single BC4 throughout development, but are contacted by multiple BC4s through ongoing dendritic elaboration b

SUBMITTER: Simmons AB 

PROVIDER: S-EPMC7346645 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature