EGR2 is elevated and positively regulates inflammatory IFNγ production in lupus CD4⁺ T cells.

ABSTRACT:

Background

Recent studies have shown that early growth response 2 (EGR2) is highly induced in activated T cells and regulates T cell functions. In normal C57BL/6 (B6) mice, deletion of EGR2 in lymphocytes results in the development of lupus-like systemic autoimmune disease, which implies indirectly an autoimmune protective role of EGR2. Conversely, increased EGR2 gene expression is suggested to link with high risk of human lupus. In the present studies we sought to clarify the expression and inflammation regulatory role of EGR2 in murine lupus T cells directly.

Results

We performed RT-qPCR analysis and found a significant increase of EGR2 mRNA expression in human lupus PBMCs and in CD4⁺ T cells from three different murine lupus models including MRL-lpr, B6-lpr, an

SUBMITTER: Dai R 

PROVIDER: S-EPMC7346656 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature