Novel circulating protein biomarkers for thyroid cancer determined through data-independent acquisition mass spectrometry.

ABSTRACT:

Background

Distinguishing between different types of thyroid cancers (TC) remains challenging in clinical laboratories. As different tumor types require different clinical interventions, it is necessary to establish new methods for accurate diagnosis of TC.

Methods

Proteomic analysis of the human serum was performed through data-independent acquisition mass spectrometry for 29 patients with TC (stages I-IV): 13 cases of papillary TC (PTC), 10 cases of medullary TC (MTC), and six cases follicular TC (FTC). In addition, 15 patients with benign thyroid nodules (TNs) and 10 healthy controls (HCs) were included in this study. Subsequently, 17 differentially expressed proteins were identified in 291 patients with TC, including 247 with PTC, 38 with MTC, and six with FTC, and 69 pa

SUBMITTER: Li D 

PROVIDER: S-EPMC7346861 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature