Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms.

ABSTRACT:

Introduction

This study determined whether blood DNA methylation (DNAm) patterns differentiate individuals with presymptomatic dementia compared to controls.

Methods

DNAm was measured in 73 individuals prior to dementia diagnosis and 87 cognitively healthy controls matched for age, sex, smoking, education, and baseline cognition. DNAm was also measured at 3 years follow-up in 25 dementia cases, and 24 controls.

Results

Cases and controls differed in DNAm (unadjusted P < .01) at the time of diagnosis (n = 28,787 probes), and pre-diagnosis (n = 15,111 probes), with cg01404610 (General transcription factor IIA subunit 1 gene) significant after correction for multiple testing. Overall, 1150 probes overlapped between analyses (methylation differences from -10

SUBMITTER: Fransquet PD 

PROVIDER: S-EPMC7346866 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature