Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.

ABSTRACT:

Background

People with human immunodeficiency virus (PWH) are at risk for accelerated development of physical function impairment and frailty; both associated with increased risk of falls, hospitalizations, and death. Identifying factors associated with physical function impairment and frailty can help target interventions.

Methods

The REPRIEVE trial enrolled participants 40-75 years of age, receiving stable antiretroviral therapy with CD4+ T-cell count >100 cells/mm3, and with low to moderate cardiovascular disease risk. We conducted a cross-sectional analysis of those concurrently enrolled in the ancillary study PREPARE at enrollment.

Results

Among the 266 participants, the median age was 51 years; 81% were male, and 45% were black, and 28% had hypertension. Body ma

SUBMITTER: Umbleja T 

PROVIDER: S-EPMC7347078 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature