Ontology highlight
ABSTRACT:
SUBMITTER: Miller AL
PROVIDER: S-EPMC7347093 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
PLoS pathogens 20200709 7
Reactive arthritis, an autoimmune disorder, occurs following gastrointestinal infection with invasive enteric pathogens, such as Salmonella enterica. Curli, an extracellular, bacterial amyloid with cross beta-sheet structure can trigger inflammatory responses by stimulating pattern recognition receptors. Here we show that S. Typhimurium produces curli amyloids in the cecum and colon of mice after natural oral infection, in both acute and chronic infection models. Production of curli was associat ...[more]